(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester
CAS No.:195503-58-3
Molecular Formula:C₂₉H₃₈N₄O₅S
Molecular Weight:554.711
Hs Code.:

Synonyms:(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

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Chemical Property of (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

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Technology Process of (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

There total 6 articles about (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75755-40-7
2,2-dimethyl-3-(N-methyl-N-phenylamino)-2H-azirine

: 195503-57-2
4-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-tetrahydro-thiopyran-4-carboxylic acid

: 195503-58-3
(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1002/hlca.19970800515

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 195503-58-3
(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / t-BuOK / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane / 3 h / Ambient temperature

2: 97 percent / NaOH / ethanol; H₂O / 5 h / Heating

3: oxalyl chloride / CH₂Cl₂ / 0 deg c, 4 h, then rt., 1 h

4: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

5: 1.) LDA, diphenyl phosphorochloridate; 2.) NaN₃ / 1.) THF/heptane/ethylbenzene, rt., 24 h; 2.) THF/heptane/ethylbenzene, rt., 3 d

6: 80 percent / acetonitrile / 16 h / Ambient temperature

7: 95 percent / 6N HCl / tetrahydrofuran / 4 h / Ambient temperature

8: 76 percent / tetrahydrofuran / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium azide; oxalyl dichloride; potassium tert-butylate; triethylamine; chlorophosphoric acid diphenyl ester; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/hlca.19970800515

Reference yield:

: 195503-40-3
tetrahydro-2H-thiopyrane-4-carbonitrile

: 195503-58-3
(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / NaOH / ethanol; H₂O / 5 h / Heating

2: oxalyl chloride / CH₂Cl₂ / 0 deg c, 4 h, then rt., 1 h

3: Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) LDA, diphenyl phosphorochloridate; 2.) NaN₃ / 1.) THF/heptane/ethylbenzene, rt., 24 h; 2.) THF/heptane/ethylbenzene, rt., 3 d

5: 80 percent / acetonitrile / 16 h / Ambient temperature

6: 95 percent / 6N HCl / tetrahydrofuran / 4 h / Ambient temperature

7: 76 percent / tetrahydrofuran / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium azide; oxalyl dichloride; triethylamine; chlorophosphoric acid diphenyl ester; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.19970800515