195503-40-3

Basic information

• Product Name: TETRAHYDROTHIOPYRAN-4-CARBONITRILE
• Synonyms: TETRAHYDROTHIOPYRAN-4-CARBONITRILE;Tetrahydro-2H-thiopyran-4-carbonitrile;Tetrahydro-2H-thiopyran-4-carbonitrile 97%;2H-Thiopyran-4-carbonitrile, tetrahydro-;tetrahydro-2H-thiopyrane-4-carbonitrile;thiane-4-carbonitrile;Tetrahydro-2H-thiopyran-4-carbonitrile97%
• CAS NO: 195503-40-3
• Molecular Formula: C₆H₉NS
• Molecular Weight: 127.20736
• Mol File: 195503-40-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 263.2 °C at 760 mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TETRAHYDROTHIOPYRAN-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROTHIOPYRAN-4-CARBONITRILE(195503-40-3)
• EPA Substance Registry System: TETRAHYDROTHIOPYRAN-4-CARBONITRILE(195503-40-3)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 195503-40-3(Hazardous Substances Data)

Usage

General Description

Tetrahydrothiopyran-4-carbonitrile is a chemical compound with the molecular formula C6H9NS. It is a heterocyclic compound containing a ring of five carbon atoms, one sulfur atom, and one nitrogen atom. TETRAHYDROTHIOPYRAN-4-CARBONITRILE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Tetrahydrothiopyran-4-carbonitrile has been studied for its potential biological activities, such as antitumor and antibacterial properties. Its chemical structure and reactivity make it a valuable intermediate in organic synthesis for the production of various compounds with important applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C6H9NS/c7-5-6-1-3-8-4-2-6/h6H,1-4H2

Upstream product

• 1072-72-6 Tetrahydrothiopyran-4-one 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 14562-04-0 toluene-4-sulfonic acid cyanomethyl ester 
• 50675-19-9 4-thianylcarbaldehyde 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 

Downstream Products

• 50675-19-9 4-thianylcarbaldehyde 
• 100277-27-8 (tetrahydro-2H-thiopyran-4-yl)methanol 
• 64096-87-3 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carboxylic acid 
• 917807-18-2 methyl tetrahydro-2H-thiopyran-4-carboxylate-1,1-dioxide 
• 1262411-34-6 4-methyltetrahydro-2H-thiopyran-4-carboxylic acid 
• 1361951-03-2 N-((tetrahydro-2H-thiopyran-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 
• 1361950-98-2 4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)tetrahydro-2H-thiopyran 1,1-dioxide 
• 928149-12-6 (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate 
• 473254-28-3 (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol 
• 950603-21-1 tetrahydrothiopyran-4-ylmethylamine hydrochloride 
• 195503-58-3 (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-thiopyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester 

Relevant articles and documents

Expansion of substrate scope for nitroxyl radical/copper-catalyzed aerobic oxidation of primary alcohols: A guideline for catalyst selection

Four distinctive sets of optimum nitroxyl radical/copper salt/additive catalyst combinations have been identified for accommodating the aerobic oxidation of various types of primary alcohols to their corresponding aldehydes. Interestingly, less nucleophilic catalysts exhibited higher catalytic activities for the oxidation of particular primary allylic and propargylic alcohols to give α,β-unsaturated aldehydes that function as competent Michael acceptors. The optimum conditions identified herein were successful in the oxidation of various types of primary alcohols, including unprotected amino alcohols and divalent-sulfur-containing alcohols in good-to-high yields. Moreover, N-protected alaninol, an inefficient substrate in the nitroxyl radical/ copper-catalyzed aerobic oxidation, was oxidized in good yield. On the basis of the optimization results, a guideline for catalyst selection has been established.

IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors

The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.