3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

Base Information

Chemical Name:3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride
CAS No.:1265228-26-9
Molecular Formula:C₂₅H₂₅F₃N₆O₅*ClH
Molecular Weight:582.967
Hs Code.:

Synonyms:3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

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Chemical Property of 3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

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Technology Process of 3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

There total 3 articles about 3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 876126-60-2
4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

: 1265228-20-3
2-chloro-4-(4-nitrophenyloxy)-5-trifluoromethylpyrimidine

: 1265228-26-9
3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

Guidance literature:: 4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; With chloro-trimethyl-silane; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol; at 70 ℃; for 1h;

2-chloro-4-(4-nitrophenyloxy)-5-trifluoromethylpyrimidine; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol; at 70 ℃; for 17h;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1265228-26-9
3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / isopropyl alcohol / 0.67 h / 20 °C

1.2: 16.5 h / -15 - 20 °C

2.1: chloro-trimethyl-silane / isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 1 h / 70 °C

2.2: 17 h / 70 °C

With chloro-trimethyl-silane; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1265228-26-9
3-methoxy-N-(1-methyl-piperidin-4-yl)-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / isopropyl alcohol / 0.67 h / 20 °C

1.2: 16.5 h / -15 - 20 °C

2.1: chloro-trimethyl-silane / isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 1 h / 70 °C

2.2: 17 h / 70 °C

With chloro-trimethyl-silane; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol;