N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

Base Information

Chemical Name:N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide
CAS No.:1018468-47-7
Molecular Formula:C₂₅H₂₇FN₈O
Molecular Weight:474.541
Hs Code.:

Synonyms:N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

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Technology Process of N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

There total 2 articles about N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1018473-23-8
(6-(5-amino-3-methylpyrazol-1-yl)pyrimidin-4-yl)methylamine

: N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-3-iodo-4-methylbenzamide

: 1018468-47-7
N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 1h; Sealed vial;

Reference yield:

: 1018473-22-7
C₈H₈ClN₅

: 1018468-47-7
N-(5-(1-fluoro-1-methylethyl)pyridin-3-yl)-4-methyl-3-(5-methyl-2-(6-methylaminopyrimidin-4-yl)-2H-pyrazol-3-ylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; isopropyl alcohol / 4 h / 50 °C / Sealed tube

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 150 °C / Sealed vial

With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; isopropyl alcohol;