4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1306722-76-8
Molecular Formula:C₁₉H₂₅N₃O₅S
Molecular Weight:407.491
Hs Code.:

Synonyms:4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 590-93-2
2-Butynoic acid

: 173951-84-3
4-((4-aminophenyl)sulfonyl)-1-(tert-butyloxycarbonyl)piperazine

: 1306722-76-8
4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201310y

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1306722-76-8
4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 2 h / 80 °C

3: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

With pyridine; iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm201310y

Reference yield:

: 173951-83-2
N-((4-nitrophenyl)sulfonyl)-1-(tert-butyloxycarbonyl)piperazine

: 1306722-76-8
4-[4-(1-oxobut-2-ynylamino)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / 2 h / 80 °C

2: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

With pyridine; iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water;
DOI:10.1021/jm201310y