N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether

Base Information

• Chemical Name: N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether
• CAS No.: 943443-89-8
• Molecular Formula: C₃₆H₄₃N₄O₈
• Molecular Weight: 659.759
• Mol file: 943443-89-8.mol

Synonyms:N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether

Chemical Property of N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether

There total 1 articles about N^ω-benzyloxycarbonyl-N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Nε-carbobenzoxy-L-lysine benzyl ester hydrochloride (6366-70-7) + 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetic acid (145757-48-8) → Nω-benzyloxycarbonyl-Nα-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether (943443-89-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 16h; pH=9;

DOI:10.1016/j.bmcl.2008.02.030

Reference yield: 90.0%

Nω-benzyloxycarbonyl-Nα-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether (943443-89-8) → Nα-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine (943443-91-2)

Guidance literature:

With trifluorormethanesulfonic acid; trifluoroacetic acid; at 0 ℃; for 1h;

DOI:10.1016/j.bmcl.2008.02.030

Reference yield:

Nω-benzyloxycarbonyl-Nα-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine benzyl ether (943443-89-8) → C29H37N4O8 (943443-90-1)

Guidance literature:

With sodium hydroxide; under 750.075 Torr;

DOI:10.1016/j.bmc.2008.01.022

upstream raw materials:

N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride

1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetic acid

Downstream raw materials:

N^α-[4-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)phenyloxyacetyl]-L-lysine

C₂₉H₃₇N₄O₈