N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

Base Information

Chemical Name:N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea
CAS No.:1395922-19-6
Molecular Formula:C₂₇H₃₄ClN₃O₃
Molecular Weight:484.038
Hs Code.:

Synonyms:N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

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Chemical Property of N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

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Technology Process of N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

There total 7 articles about N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.1%

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride

: 104-12-1
p-chlorphenylisocyanate

: 1395922-19-6
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

Guidance literature:: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride; p-chlorphenylisocyanate; In acetonitrile; at 20 ℃;

With sodium hydrogencarbonate; In acetonitrile;

Reference yield:

: 6698-13-1
4-bromo-benzo[1,3]dioxole

: 1395922-19-6
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: acetonitrile / 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1395922-19-6
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-3-(4-chloro-phenyl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: acetonitrile / 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile;