4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

Base Information

Chemical Name:4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride
CAS No.:130621-74-8
Molecular Formula:C₁₄H₁₅N₃O₅*ClH
Molecular Weight:341.751
Hs Code.:

Synonyms:4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

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Chemical Property of 4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

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Technology Process of 4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

There total 4 articles about 4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 130620-74-5
4-{[(S)-2-tert-Butoxycarbonylamino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid

: 130621-74-8
4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.1199

Reference yield:

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 130621-74-8
4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / diethylphosphoryl cyanide, NEt₃ / dimethylformamide / 1 h

2: 92 percent / 0.5 N NaOH / methanol / 0.5 h

3: 89 percent / 4 N HCl / dioxane / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diethylphosphoryl cyanide; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1199

Reference yield:

: 127608-01-9
N-tert-butoxycarbonyl-TAN-950 A

: 130621-74-8
4-{[(S)-2-Amino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / diethylphosphoryl cyanide, NEt₃ / dimethylformamide / 1 h

2: 92 percent / 0.5 N NaOH / methanol / 0.5 h

3: 89 percent / 4 N HCl / dioxane / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; diethylphosphoryl cyanide; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1199