(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester
CAS No.:859205-93-9
Molecular Formula:C₃₀H₃₃ClFN₅O₅
Molecular Weight:598.074
Hs Code.:

(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

Synonyms:(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

There total 6 articles about (S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₂₀H₁₅Cl₂FN₄O

: 135065-76-8
tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

: 859205-93-9
(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 65 ℃;

Reference yield:

: 529508-56-3
4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine

: 859205-93-9
(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 20 °C

2: NBS; benzoyl peroxide / CCl₄ / 0.17 h / Heating

3: toluene / Heating

4: m-CPBA / CH₂Cl₂ / 0.5 h / 0 - 20 °C

5: CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2007.01.002

Reference yield:

: 859205-88-2
5-methyl-4-(methylthio)pyrrolo[2,1-f][1,2,4]triazine

: 859205-93-9
(S)-2-{4-[3-chloro-4-(3-fluoro-benzyloxy)-5 phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethoxy methyl}-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NBS; benzoyl peroxide / CCl₄ / 0.17 h / Heating

2: toluene / Heating

3: m-CPBA / CH₂Cl₂ / 0.5 h / 0 - 20 °C

4: CH₂Cl₂ / 20 °C

With N-Bromosuccinimide; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2007.01.002