(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

Base Information

Chemical Name:(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone
CAS No.:1289155-12-9
Molecular Formula:C₂₄H₃₁FN₄O₃S
Molecular Weight:474.6
Hs Code.:

Synonyms:(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

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Chemical Property of (S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

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Technology Process of (S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

There total 6 articles about (S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1289261-26-2
C₁₁H₁₆N₂O₂S

: 923170-82-5
2-chloro-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

: 1289155-12-9
(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

Guidance literature:: With potassium iodide; In tetrahydrofuran; for 20h; Reflux;
DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

: 1289154-99-9
tert-butyl (S)-(1-(benzylsulfonyl)pyrrolidin-3-yl)carbamate

: 1289155-12-9
(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: potassium iodide / tetrahydrofuran / 20 h / Reflux

With hydrogenchloride; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

: 1289155-00-5
(S)-1-(benzylsulfonyl)pyrrolidin-3-aminium chloride

: 1289155-12-9
(S)-2-((1-(benzylsulfonyl)pyrrolidin-3-yl)amino)-1-(4-(2-fluorobenzyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: potassium iodide / tetrahydrofuran / 20 h / Reflux

With triethylamine; potassium iodide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.01.020