7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

Base Information

Chemical Name:7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide
CAS No.:958328-91-1
Molecular Formula:C₂₃H₂₇N₃O₃S
Molecular Weight:425.552
Hs Code.:

Synonyms:7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

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Chemical Property of 7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

Chemical Property:

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Technology Process of 7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

There total 9 articles about 7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.7%

: 886842-78-0
N-{4-[(1R)-1-aminoethyl]-2-methylphenyl}methanesulfonamide hydrochloride

: 958331-92-5
7-ISOPROPYLQUINOLINE-3-CARBOXYLIC ACID

: 958328-91-1
7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 958331-85-6
ETHYL 4-CHLORO-7-ISOPROPYLQUINOLINE-3-CARBOXYLATE

: 958328-91-1
7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogen / 5%-palladium/activated carbon / ethanol / 3 h / 20 °C

2: sodium hydroxide; water / ethanol / 3 h / 80 °C

3: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 4 h / 20 °C

With water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; 5%-palladium/activated carbon; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 958334-16-2
ethyl 7-isopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 958328-91-1
7-Isopropyl-quinoline-3-carboxylic acid [(R)-1-(4-methanesulfonylamino-3-methyl-phenyl)-ethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 120 °C

2: triethylamine; hydrogen / 5%-palladium/activated carbon / ethanol / 3 h / 20 °C

3: sodium hydroxide; water / ethanol / 3 h / 80 °C

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 4 h / 20 °C

With water; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In ethanol; N,N-dimethyl-formamide;