{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

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Chemical Name:{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane
CAS No.:854931-26-3
Molecular Formula:C₅₄H₇₀O₇Si
Molecular Weight:859.231
Hs Code.:

{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

Synonyms:{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

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Chemical Property of {2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

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Technology Process of {2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

There total 16 articles about {2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 854749-23-8
(E)-4-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-4-methyl-pent-2-enal

: 419541-71-2
(3S)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropil)hex-5-en-3-ol

: 854931-26-3
{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at -78 ℃;
DOI:10.1021/ol050511w

Reference yield:

: (2R,3R)-2-((benzyloxy)methoxy)hex-5-en-3-ol

: 854931-26-3
{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 13 steps

1: KH / tetrahydrofuran

2: O₃; NaHCO₃ / CH₂Cl₂; methanol / -78 °C

3: MgBr₂*Et₂O

4: 97 percent / imidazole / dimethylformamide

5: 92 percent / Rh(acac)2(CO)2; triarylphosphite-based ligand; H₂

6: 92 percent / indium / dimethylformamide

7: 94 percent / PCC; molecular sieves 4 Angstroem; NaOAc / CH₂Cl₂

8: O₃

9: 92 percent / NaH

10: HF*pyridine

11: camphorsulfonic acid / benzene / Heating

12: 84 percent / DIBAL-H / -78 °C

13: 66 percent / trimethylsilyl triflate / diethyl ether / -78 °C

With 1H-imidazole; indium; trimethylsilyl trifluoromethanesulfonate; Rh(acac)2(CO)2; 4 A molecular sieve; triarylphosphite-based ligand; camphor-10-sulfonic acid; hydrogen; sodium acetate; potassium hydride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; ozone; pyridinium chlorochromate; magnesium bromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 9: Horner-Emmons reaction;
DOI:10.1021/ol050511w

Reference yield:

: 1-[(R)-1-((R)-1-Benzyloxymethoxy-ethyl)-but-3-enyloxymethyl]-4-methoxy-benzene

: 854931-26-3
{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 12 steps

1: O₃; NaHCO₃ / CH₂Cl₂; methanol / -78 °C

2: MgBr₂*Et₂O

3: 97 percent / imidazole / dimethylformamide

4: 92 percent / Rh(acac)2(CO)2; triarylphosphite-based ligand; H₂

5: 92 percent / indium / dimethylformamide

6: 94 percent / PCC; molecular sieves 4 Angstroem; NaOAc / CH₂Cl₂

7: O₃

8: 92 percent / NaH

9: HF*pyridine

10: camphorsulfonic acid / benzene / Heating

11: 84 percent / DIBAL-H / -78 °C

12: 66 percent / trimethylsilyl triflate / diethyl ether / -78 °C

With 1H-imidazole; indium; trimethylsilyl trifluoromethanesulfonate; Rh(acac)2(CO)2; 4 A molecular sieve; triarylphosphite-based ligand; camphor-10-sulfonic acid; hydrogen; sodium acetate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; pyridine hydrogenfluoride; ozone; pyridinium chlorochromate; magnesium bromide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 8: Horner-Emmons reaction;
DOI:10.1021/ol050511w