6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol

Base Information

• Chemical Name: 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol
• CAS No.: 854749-34-1
• Molecular Formula: C₅₆H₇₈O₁₂
• Molecular Weight: 943.228
• Mol file: 854749-34-1.mol

Synonyms:

Chemical Property of 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol

There total 9 articles about 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-((tert-butyldiphenylsilyl)oxy)-3-((4-methoxybenzyl)oxy)pentanal (854749-30-7) → 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol (854749-34-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / MgBr₂*Et₂O / -78 °C

2: 80 percent / trimethylsilyl triflate / diethyl ether / -78 °C

3: mCPBA

4: tetra-n-butylammonium fluoride

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; magnesium bromide; In diethyl ether;

DOI:10.1021/ol050512o

Reference yield:

(4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol (854749-31-8) → 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol (854749-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / trimethylsilyl triflate / diethyl ether / -78 °C

2: mCPBA

3: tetra-n-butylammonium fluoride

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In diethyl ether;

DOI:10.1021/ol050512o

Reference yield:

[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-acetaldehyde (854749-32-9) → 6-[3-benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-2-[3-(6-{6-[4-hydroxy-2-(4-methoxy-benzyloxy)-butyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-1,1-dimethyl-allyl]-2-methoxy-tetrahydro-pyran-3-ol (854749-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / trimethylsilyl triflate / diethyl ether / -78 °C

2: mCPBA

3: tetra-n-butylammonium fluoride

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In diethyl ether;

DOI:10.1021/ol050512o

upstream raw materials:

(S)-5-((tert-butyldiphenylsilyl)oxy)-3-((4-methoxybenzyl)oxy)pentanal

(4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-acetaldehyde

{2-[(2S,6R)-6-((E)-3-{(S)-6-[(2R,3R)-3-Benzyloxymethoxy-2-(4-methoxy-benzyloxy)-butyl]-5,6-dihydro-4H-pyran-2-yl}-3-methyl-but-1-enyl)-4-methylene-tetrahydro-pyran-2-yl]-ethoxy}-tert-butyl-diphenyl-silane

Downstream raw materials:

C₄₀H₅₆O₁₀

(R)-4-[(2S,6R)-6-((2S,6R)-6-{(E)-3-[(2S,6S)-6-((2R,3R)-3-Benzyloxymethoxy-2-hydroxy-butyl)-2-methoxy-3-oxo-tetrahydro-pyran-2-yl]-3-methyl-but-1-enyl}-4-methylene-tetrahydro-pyran-2-ylmethyl)-4-methylene-tetrahydro-pyran-2-yl]-3-hydroxy-butyric acid