(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

Base Information

Chemical Name:(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine
CAS No.:1456882-15-7
Molecular Formula:C₃₆H₃₀F₁₂N₄
Molecular Weight:746.642
Hs Code.:

Synonyms:(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

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Chemical Property of (2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

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Technology Process of (2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

There total 6 articles about (2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄H₆O₆*C₈H₁₆N₂

: 1456882-13-5
5-(2,6-bis(trifluoromethyl)phenyl)-2-(chloromethyl)pyridine

: 1456882-15-7
(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 12h;
DOI:10.1021/ja407388y

Reference yield:

: 1351378-73-8
2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1456882-15-7
(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 16 h / 100 °C / Inert atmosphere

2: hydrogenchloride / water; ethanol / 3 h

3: thionyl chloride / dichloromethane / 12 h

4: sodium hydroxide / dichloromethane; water / 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; potassium phosphate; thionyl chloride; palladium diacetate; sodium hydroxide; In ethanol; dichloromethane; water; toluene;
DOI:10.1021/ja407388y

Reference yield:

: 1456882-12-4
5-(2,6-bis(trifluoromethyl)phenyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine

: 1456882-15-7
(2R,2’R)-1,1’-bis((5-(2,6-bis(trifluoromethyl)phenyl)pyridin-2-yl)methyl)-2,2’-bipyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; ethanol / 3 h

2: thionyl chloride / dichloromethane / 12 h

3: sodium hydroxide / dichloromethane; water / 12 h / 20 °C

With hydrogenchloride; thionyl chloride; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/ja407388y