2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

Base Information

Chemical Name:2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide
CAS No.:1052721-10-4
Molecular Formula:C₁₉H₁₆F₂N₂O₄S₂
Molecular Weight:438.476
Hs Code.:

Synonyms:2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

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Chemical Property of 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

Chemical Property:

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Technology Process of 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

There total 6 articles about 2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1052722-22-1
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid

: 1052721-10-4
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 300355-18-4
(4-methanesulfonyl-phenyl)-acetic acid methyl ester

: 1052721-10-4
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C

1.2: -78 - 20 °C

2.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 1 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 - 3 h / 60 - 70 °C

4.1: methanol; sodium hydroxide; water / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; N-Bromosuccinimide; n-butyllithium; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1052722-20-9
2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester

: 1052721-10-4
2-(2,4-difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 1 h / Heating / reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 - 3 h / 60 - 70 °C

3: methanol; sodium hydroxide; water / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With methanol; sodium hydroxide; N-Bromosuccinimide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;