300355-18-4

Usage

General Description

Methyl 2-(4-(methylsulfonyl)phenyl)acetate is a chemical compound with the molecular formula C11H14O4S. It is an ester, which means it is derived from an acid in which at least one -OH (hydroxyl) group is replaced by an -O-alkyl group. This particular ester contains a phenyl ring with a methylsulfonyl group attached to it. Methyl 2-(4-(methylsulfonyl)phenyl)acetate is commonly used as a flavoring agent in the food industry and as a fragrance in the perfume industry. It may also have other industrial or pharmaceutical applications due to its aromatic and functional group properties.

Upstream product

• 16188-55-9 2-(4-(methylthio)phenyl)acetic acid 
• 90536-66-6 4-(methylsulfonyl)phenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 1360789-02-1 2-(4-(methylsulfonyl)phenyl)-1-(2,2,6,6-tetramethylpiperidin-1-yl)ethanone 
• 70290-37-8 (4-methylsulfanyl-phenyl)-acetic acid methyl ester 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 300355-19-5 3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid methyl ester 
• 557798-35-3 bromo-(4-methylsulfonyl-phenyl)-acetic acid methyl ester 
• 1380645-95-3 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(5-methyl-pyrazin-2-yl)-propionamide 
• 1380645-96-4 3-(4-Fluoro-phenyl)-N-(6-hydroxymethyl-benzooxazol-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380645-97-5 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(5-methoxymethyl-pyrazin-2-yl)-propionamide 
• 1380645-99-7 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(5-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-pyrazin-2-yl)-propionamide 
• 1380646-01-4 N-(6-Chloro-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380646-02-5 3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380646-11-6 3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-N-(4-methyl-benzooxazol-2-yl)-propionamide 
• 1380646-16-1 N-(6-Fluoro-benzooxazol-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380646-25-2 acetic acid 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionylamino]-pyrazin-2-ylmethyl ester 
• 1380646-32-1 (S)-3-(4-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380646-31-0 (R)-3-(4-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide 
• 1380646-64-9 5-[3-(4-fluoro-phenyl)-2-(4-methanesulfonylphenyl)propionylamino]-pyrazine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC CARBOXYLIC ACID AMIDE LIGAND AND APPLICATIONS THEREOF IN COPPER CATALYZED COUPLING REACTION OF ARYL HALOGENO SUBSTITUTE

Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions

The amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing the formation of a wide range of (hetero)aryl sulfones from the corresponding (hetero)aryl halides at considerably low catalytic loadings. The coupling of (hetero)aryl iodides and sodium methanesulfinate proceeds at room temperature with only 0.5 mol % CuI and ligand, representing the first example for Cu-catalyzed arylation at both low catalytic loading and room temperature.

FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE DERIVATIVES AND THEIR USE AS PHD INHIBITORS

The present invention provides compounds of formula (I) which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for treatment of conditions associated with HIF, processes for making the compounds and intermediates thereof.

TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Switching pathways: Room-temperature neutral solvolysis and substitution of amides

Stick or twist: By introducing steric hindrance at the nitrogen atom, stable linear amides bearing an electron-withdrawing α-substituent (Z=Ar, PhSO2, P(O)(OR)2, CN, or CO2R) can be induced to undergo solvolysis and substitution reactions through an elimination-addition mechanism (see picture). Key to this process is a low barrier to rotation around the amide bond and the α-substituentZ. Copyright

Amido Compounds

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein the variables are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES

The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and to a method for the treatment an acute or chronic inflammatory disease by inhibiting the production of at least one pro-inflamma

5-(4-methanesulfonyl-phenyl)-thiazole derivatives for the treatment of acute and chronic inflammatory diseases

The invention relates to the use of a compound of formula (I): or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in the preparation of a medicament for the treatment of an acute or chronic inflammatory disease, by inhibiting the produ

Heteroaromatic Glucokinase Activators

The present invention describes 2,3-di-substituted N-heteroaromatic propionamides, of Formula (I) wherein the substitution at the 3-position is an optionally substituted phenyl ring and the substitution at the 2-position is an alkyl or cycloalkyl group; p