2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

Base Information

Chemical Name:2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine
CAS No.:1352834-86-6
Molecular Formula:C₂₁H₁₉FN₄O
Molecular Weight:362.406
Hs Code.:

Synonyms:2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

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Chemical Property of 2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

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Technology Process of 2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

There total 6 articles about 2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1352834-85-5
3-(1-(2-fluorophenyl)-2-nitroethyl)-6-methyl-5-(pyrimidin-5-yloxy)-1H-indole

: 1352834-86-6
2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: With hydrogen; Raney Ni; In methanol; for 3h; under 2740.96 Torr;

Reference yield:

: 553-94-6
4-bromo-m-xylene

: 1352834-86-6
2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; sulfuric acid; acetic acid / 1.75 h / 8 - 10 °C

2: caesium carbonate / copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / 1-methyl-pyrrolidin-2-one / 130 °C / Sealed tube

3: N,N-dimethyl-formamide / 0.75 h / 115 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / methanol

5: 4 h / 130 °C

6: hydrogen / Raney Ni / methanol / 3 h / 2740.96 Torr

With sulfuric acid; hydrogen; nitric acid; caesium carbonate; acetic acid; 2,2,6,6-tetramethylheptane-3,5-dione; palladium 10% on activated carbon; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;

Reference yield:

: 15540-81-5
1-bromo-2,5-dimethyl-4-nitrobenzene

: 1352834-86-6
2-(2-fluorophenyl)-2-(6-methyl-5-(pyrimidin-5-yloxy)-1H-indol-3-yl)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / 1-methyl-pyrrolidin-2-one / 130 °C / Sealed tube

2: N,N-dimethyl-formamide / 0.75 h / 115 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol

4: 4 h / 130 °C

5: hydrogen / Raney Ni / methanol / 3 h / 2740.96 Torr

With hydrogen; caesium carbonate; 2,2,6,6-tetramethylheptane-3,5-dione; palladium 10% on activated carbon; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;