[5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide

Base Information

• Chemical Name: [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide
• CAS No.: 1628918-18-2
• Molecular Formula: C₂₉H₂₂NO₄P
• Molecular Weight: 479.472
• Mol file: 1628918-18-2.mol

Synonyms:[5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide

Chemical Property of [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide

There total 3 articles about [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(Z)-5-(2-nitrophenyl)-3-phenylpent-2-en-4-ynal (1628918-23-9) + Diphenylphosphine oxide (4559-70-0) → [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide (1628918-18-2)

Guidance literature:

With potassium phosphate; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

DOI:10.1055/s-0033-1340865

Reference yield:

(Z)-β-bromocinnamaldehyde (14804-59-2,33603-88-2) → [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide (1628918-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; palladium dichloride; triphenylphosphine; copper(l) iodide / acetonitrile / 1 h / 20 °C

2: potassium phosphate / tetrahydrofuran / 50 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; acetonitrile;

DOI:10.1055/s-0033-1340865

Reference yield:

2-ethynyl-1-nitrobenzene (16433-96-8) → [5-(2-nitrobenzyl)-4-phenylfuran-2-yl]diphenylphosphine oxide (1628918-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; palladium dichloride; triphenylphosphine; copper(l) iodide / acetonitrile / 1 h / 20 °C

2: potassium phosphate / tetrahydrofuran / 50 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride; In tetrahydrofuran; acetonitrile;

DOI:10.1055/s-0033-1340865

upstream raw materials:

(Z)-β-bromocinnamaldehyde

2-ethynyl-1-nitrobenzene

(Z)-5-(2-nitrophenyl)-3-phenylpent-2-en-4-ynal

Diphenylphosphine oxide