(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

Base Information

Chemical Name:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid
CAS No.:343256-66-6
Molecular Formula:C₂₀H₃₀N₂O₄
Molecular Weight:362.469
Hs Code.:

Synonyms:(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

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Chemical Property of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

Chemical Property:

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Technology Process of (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

There total 9 articles about (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025946-22-8
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid tert-butyl ester

: 343256-66-6
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

Guidance literature:: With trifluoroacetic acid; for 1h;
DOI:10.1021/jm970404a

Reference yield:

: 156109-64-7
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-phenylpentanoic acid

: 343256-66-6
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: EDC; HOBt; Et₃N / CH₂Cl₂ / 18 h / 20 °C

2: 99 percent / H₂ / Pd/C / ethanol; H₂O / 20 °C / 2250.18 Torr

3: PyAOP; collidine / CH₂Cl₂ / 0 - 20 °C

4: HCl gas / CH₂Cl₂ / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1016/S0960-894X(00)00719-8

Reference yield:

: 154092-64-5
tert-leucine benzyl ester

: 343256-66-6
(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: EDC; HOBt; Et₃N / CH₂Cl₂ / 18 h / 20 °C

2: 99 percent / H₂ / Pd/C / ethanol; H₂O / 20 °C / 2250.18 Torr

3: PyAOP; collidine / CH₂Cl₂ / 0 - 20 °C

4: HCl gas / CH₂Cl₂ / 0 - 20 °C

With 2,3,5-trimethyl-pyridine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1016/S0960-894X(00)00719-8