[2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: [2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER
• CAS No.: 705970-56-5
• Molecular Formula: C17H15 Cl N2 O2
• Molecular Weight: 314.77
• Mol file: 705970-56-5.mol

Synonyms:[2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER

Chemical Property of [2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.58E-09mmHg at 25°C
• Refractive Index: 1.616
• Boiling Point: 474.6°C at 760 mmHg
• Flash Point: 240.8°C
• PSA: 44.12000
• Density: 1.26g/cm³
• LogP: 3.91980

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER

There total 4 articles about [2-(4-CHLORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chlorophenyl)benzimidazole (1019-85-8) + chloroacetic acid ethyl ester (105-39-5) → (2-(4-chlorophenyl)-1H-benzimidazol-1-yl)-acetic acid ethyl ester (705970-56-5)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; for 2h;

DOI:10.1016/j.bmc.2008.02.077

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (2-(4-chlorophenyl)-1H-benzimidazol-1-yl)-acetic acid ethyl ester (705970-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

With sodium metabisulfite; potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1111/j.1747-0285.2012.01347.x

Reference yield:

1,2-diamino-benzene (95-54-5) → (2-(4-chlorophenyl)-1H-benzimidazol-1-yl)-acetic acid ethyl ester (705970-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium metabisulfite

2: potassium hydroxide / dimethyl sulfoxide

With sodium metabisulfite; potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1002/ardp.201300324

upstream raw materials:

ethyl bromoacetate

2-(4-chlorophenyl)benzimidazole

chloroacetic acid ethyl ester

4-chlorobenzaldehyde

Downstream raw materials:

C₂₂H₁₈ClN₅OS

C₂₂H₁₇ClFN₅OS

C₂₂H₁₇BrClN₅OS

C₂₃H₂₀ClN₅OS