trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

Base Information

Chemical Name:trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide
CAS No.:1239311-39-7
Molecular Formula:C₂₇H₃₂N₄O₄S
Molecular Weight:508.641
Hs Code.:

Synonyms:trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

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Chemical Property of trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

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Technology Process of trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

There total 8 articles about trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616-30-8,13552-31-3,98923-21-8
3-Amino-1,2-propanediol

: 1239310-63-4
trans-{4-[4-(5-benzyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenyl]cyclohexyl}acetic acid

: 1239311-39-7
trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1237147-83-9
ethyl 4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoate

: 1239311-39-7
trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1237147-81-7
4-(4-tert-butoxycarbonylmethylcyclohexyl)benzoic acid

: 1239311-39-7
trans-N-(5-benzyl[1,3,4]thiadiazol-2-yl)-4-{4-[(2,3-dihydroxypropylcarbamoyl)methyl]-cyclohexyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 20 °C

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;