1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea

Base Information

• Chemical Name: 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea
• CAS No.: 1258961-70-4
• Molecular Formula: C₂₀H₂₁BClF₃N₂O₃
• Molecular Weight: 440.658

Synonyms:1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea

Chemical Property of 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea

Chemical Property:

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Technology Process of 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea

There total 4 articles about 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-3-(trifluoromethyl)phenyl isocyanate (327-78-6) + 3-aminophenylboronic acid pinacolate (210907-84-9) → 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea (1258961-70-4)

Guidance literature:

In dichloromethane;

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) → 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea (1258961-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / tetrahydrofuran / 5 h / 20 °C

2: dichloromethane / 0.33 h

With magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2015.08.045

Reference yield:

3-Aminophenylboronic acid (30418-59-8,280563-63-5) → 1-(4-chloro-3-trifluoromethyl-phenyl)-3-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea (1258961-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / tetrahydrofuran / 5 h / 20 °C

2: dichloromethane / 0.33 h

With magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2015.08.045

upstream raw materials:

4-chloro-3-(trifluoromethyl)phenyl isocyanate

3-aminophenylboronic acid pinacolate

3-Aminophenylboronic acid

2,3-dimethyl-2,3-butane diol

Downstream raw materials:

2-(2-amino-pyrimidin-4-yl)-3-{3-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-phenyl}-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

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