3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

Base Information

Chemical Name:3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine
CAS No.:190447-81-5
Molecular Formula:C₂₆H₃₇N₅O₈
Molecular Weight:547.608
Hs Code.:

Synonyms:3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

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Chemical Property of 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

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Technology Process of 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

There total 9 articles about 3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 190447-79-1
methyl N-(butoxycarbonyl)-3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-L-alanine

: 190447-81-5
3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

Guidance literature:: With lithium hydroxide; In methanol; for 72h; Ambient temperature;
DOI:10.1021/jm960799i

Reference yield:

: 52707-54-7,52707-59-2,64847-77-4
4-cyanobenzaldehyde oxime

: 190447-81-5
3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

Guidance literature:: Multi-step reaction with 9 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

5: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

6: TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

7: 59 percent / H₂ / 10percent Pd/C / ethanol / 19 h / 760 Torr / Ambient temperature

8: 91 percent / Et₃N / CH₂Cl₂ / 26 h / Ambient temperature

9: 82 percent / 0.69 M aq. LiOH / methanol / 72 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; sodium hypochlorite; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i

Reference yield:

: 170229-13-7
[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid

: 190447-81-5
3-[({3-[4-({[(1,1-dimethylethoxy)carbonyl]amino}iminomethyl)phenyl]-4,5-dihydro-5-isoxazolyl}acetyl)methylamino]-N-(butoxycarbonyl)-L-alanine

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

4: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

5: TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

6: 59 percent / H₂ / 10percent Pd/C / ethanol / 19 h / 760 Torr / Ambient temperature

7: 91 percent / Et₃N / CH₂Cl₂ / 26 h / Ambient temperature

8: 82 percent / 0.69 M aq. LiOH / methanol / 72 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; ammonia; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960799i