8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

• Chemical Name: 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one
• CAS No.: 1017803-45-0
• Molecular Formula: C₃₆H₄₃FN₄O₄
• Molecular Weight: 614.76
• Mol file: 1017803-45-0.mol

Synonyms:8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one

Chemical Property of 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one

There total 6 articles about 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2-bromoethyl)(4-t-butoxycarbonylamino)benzene (218943-57-8) + spiperone (749-02-0) → 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one (1017803-45-0)

Guidance literature:

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In toluene; at 90 ℃; for 48h;

DOI:10.1080/00397910701821135

Reference yield:

2-(4'-aminophenyl)ethyl alcohol (104-10-9) → 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one (1017803-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethyl acetate / 16 h / 16 °C / Inert atmosphere

2.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 2 h / 0 °C

3.1: potassium carbonate; potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 0.5 h / 90 °C / Inert atmosphere

3.2: 48 h / 90 °C / Inert atmosphere

With N-Bromosuccinimide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triphenylphosphine; potassium hydroxide; In dichloromethane; ethyl acetate; toluene;

DOI:10.1021/acs.jmedchem.8b01249

Reference yield:

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (1021-25-6) → 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-3-[4-(N-tert-butoxycarbonyl)aminophenethyl]-1,3,8-triazaspiro[4.5]decan-4-one (1017803-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium iodide; triethylamine / acetonitrile / 20 h / Inert atmosphere; Reflux

2.1: potassium carbonate; potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 0.5 h / 90 °C / Inert atmosphere

2.2: 48 h / 90 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In toluene; acetonitrile;

DOI:10.1021/acs.jmedchem.8b01249

upstream raw materials:

1-(2-bromoethyl)(4-t-butoxycarbonylamino)benzene

spiperone

2-(4'-aminophenyl)ethyl alcohol

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

Downstream raw materials:

[125I]-N-(p-Aminophenethyl)spiroperidol