(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

Base Information

Chemical Name:(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione
CAS No.:107199-37-1
Molecular Formula:C₂₀H₁₈N₂O₃
Molecular Weight:334.375
Hs Code.:

Synonyms:(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

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Chemical Property of (+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

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Technology Process of (+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

There total 4 articles about (+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 107199-26-8,107199-27-9
threo-(+/-)-Z-6-benzylidene-3-(α-bromobenzyl)-3-hydroxy-1,4-dimethylpiperazine-2,5-dione

: 107199-37-1
(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

Guidance literature:: With triethylamine; In ethyl acetate; for 2h; Heating;

Reference yield:

: 87259-95-8,107244-31-5
(+/-)-(Z)-6-benzylidene-3-(α-chlorobenzyl)-3-methoxy-1,4-dimethylpiperazine-2,5-dione

: 107199-37-1
(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / triethylamine, anhydrous potassium carbonate, H₂ / 10percent palladized charcoal / ethyl acetate

2: 76 percent / acetic acid, hydrochloric acid / 0.25 h / Heating

3: 33 percent / N-bromosuccinimide / H₂O; dioxane / Ambient temperature

4: 78 percent / triethylamine / ethyl acetate / 2 h / Heating

With hydrogenchloride; N-Bromosuccinimide; hydrogen; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 94514-45-1
1,4-dimethyl-(Z)-3-(Z)-6-dibenzylidene-2,5-piperazinedione

: 107199-37-1
(+/-)-(Z)-4,7-dimethyl-2-phenyl-6-(phenylmethylene)-1-oxa-4,7-diazaspiro<2.5>octane-5,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / N-bromosuccinimide / H₂O; dioxane / Ambient temperature

2: 78 percent / triethylamine / ethyl acetate / 2 h / Heating

With N-Bromosuccinimide; triethylamine; In 1,4-dioxane; water; ethyl acetate;