94514-45-1Relevant academic research and scientific papers
Ir-Catalyzed Double Asymmetric Hydrogenation of 3,6-Dialkylidene-2,5-diketopiperazines for Enantioselective Synthesis of Cyclic Dipeptides
Ge, Yao,Han, Zhaobin,Wang, Zheng,Ding, Kuiling
, p. 8981 - 8988 (2019/06/13)
An Ir/spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligand (SpinPHOX) complex-catalyzed double asymmetric hydrogenation of 3,6-dialkylidene-1,4-dimethylpiperazine-2,5-diones has been developed, providing efficient and practical access to a wide varie
Pyrazine Chemistry. V. Synthesis of Methylanhydropicroroccellin and Dimethylpicroroccellin
Marcuccio, Sebastian M.,Elix, John A.
, p. 1785 - 1796 (2007/10/02)
The structure of the lichen diketopiperazine, picroroccellin, has been studied by the synthesis of several of its degradation products.The three possible formulations of methylanhydropicroroccellin (3), (4) and (5) were synthesized and from the physical and chemical properties, the former two compounds were shown to be dissimilar from the naturally derived material.Furthermore, the reactivity of the 3-methoxypiperazine-2,5-dione (5) entirely paralleled that reported for picroroccellin and was consistent with the oxygen functions being located at the 3- and 6-positionsof the piperazine-2,5-dione ring.Dimethylpicroroccellin (23) was synthesized, so establishing the trans-stereochemistry of this compound.The properties of (23) were identical with those recorded for the naturally derived material.Hence we conclude that picroroccellin should be reformulated as (2).
Pyrazine Chemistry. III. Synthesis and Stereochemistry of 1,4-Dimethyl and 1,4-Diacetyl Derivatives of 3,6-Dibenzylpiperazine-2,5-dione
Marcuccio, Sebastian M.,Elix, John A.
, p. 2397 - 2402 (2007/10/02)
The trans- and (+/-)cis-isomers of 1,4-dimethyl-and 1,4-diacetyl-3,6-dibenzylpiperazine-2,5-dione were synthesized.The hydriodic acid reduction of 3,6-dibenzylidene-1,4-dimethylpiperazine-2,5-dione gave (+/-)-cis-3,6-dibenzyl-1,4-dimethylpiperazine-2,5-dione although this product has previously been assigned the trans-geometry.The unknown isolated from the permanganate oxidation of (+)-cis-1,4-diacetyl-3,6-dibenzylpiperazine-2,5-dione has been identified as the corresponding trans-isomer.
STEREOSELECTIVE SYNTHESIS OF THE GEOMETRIC AND OPTICAL ISOMERS OF UNSATURATED 3-MONO- AND 3,6-DISUBSTITUTED 2,5-PIPERAZINEDIONES
Shin, Chung-gi
, p. 1407 - 1433 (2007/10/02)
Four kinds of naturally occurring 3,6-dibenzylidene (1)-, 3-(p)-anisilidene-6-benzylidene (2)-, 3-isobutylidene-6-benzylidene (3; antibiotic albonoursin)-, and 3-benzyl-6-benzylidene-2,5-piperazinediones (4), isolated from Streptomyces and Actinomyces str
