7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Base Information

Chemical Name:7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine
CAS No.:1585145-51-2
Molecular Formula:C₂₈H₂₉Cl₂N₅O₂
Molecular Weight:538.477
Hs Code.:

Synonyms:7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

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Chemical Property of 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Chemical Property:

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Technology Process of 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

There total 10 articles about 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197333-44-0
5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

: 1585145-78-3
3-chloro-7-(2,6-dichloro-3,5-dimethoxyphenyl)isoquinoline

: 1585145-51-2
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In toluene; tert-butyl alcohol; at 120 ℃; Inert atmosphere;

Reference yield:

: 1585145-79-4
[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]carbamic acid tert-butyl ester

: 1585145-51-2
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; toluene; tert-butyl alcohol;

Reference yield:

: 192182-54-0
3,5-dimethoxyphenylboronic acid

: 1585145-51-2
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium carbonate; palladium diacetate / 1,2-dimethoxyethane; water / 90 °C / Sealed tube; Inert atmosphere

2: sulfuryl dichloride / diethyl ether / 5 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuryl dichloride; palladium diacetate; sodium carbonate; caesium carbonate; XPhos; In 1,2-dimethoxyethane; diethyl ether; water; toluene; tert-butyl alcohol;