5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

Base Information

• Chemical Name: 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine
• CAS No.: 1197333-44-0
• Molecular Formula: C₁₁H₁₈N₄
• Molecular Weight: 206.291

Synonyms:5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

Chemical Property of 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

Chemical Property:

• Boiling Point: 348.6±37.0 °C(Predicted)
• Density: 1.131±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-((4-Methylpiperazin-1-yl)methyl)pyridin-2-amine 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

There total 12 articles about 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]carbamic acid tert-butyl ester (1585145-79-4) → 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (1197333-44-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 37.0%

1-(6-chloro-pyridin-3-ylmethyl)-4-methyl-piperazine (612487-31-7) → 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (1197333-44-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium bis(trimethylsilyl)amide; CyJohnPhos; In tetrahydrofuran; at 100 ℃; for 18h; Sealed tube; Inert atmosphere;

Reference yield:

1-((6-bromopyridin-3-yl)methyl)-4-methylpiperazine (364794-55-8) → 5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (1197333-44-0)

Guidance literature:

With ([1,1’-biphenyl]-2-yl)dicyclohexylphosphine oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.12.068

upstream raw materials:

1-methyl-piperazine

6-chloronicotinylaldehyde

1-(6-chloro-pyridin-3-ylmethyl)-4-methyl-piperazine

[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]carbamic acid tert-butyl ester

Downstream raw materials:

6-tert-Butyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one

7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

7-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]isoquinolin-3-amine

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