5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

Base Information

Chemical Name:5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate
CAS No.:1374411-70-7
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

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Chemical Property of 5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

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Technology Process of 5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

There total 1 articles about 5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 65253-04-5
(-)-8-phenylmenthol

: 17874-79-2
pyridine-2,5-dicarboxylic acid 5-methyl ester

: 1374411-70-7
5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 168h; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201101427

Reference yield: 79.0%

: 1374411-70-7
5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

: 109-64-8
1,3-dibromo-propane

: 1374411-79-6
6-methyl 8a-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] (8aR)-1,2,3,8a-tetrahydroindolizine-6,8a-dicarboxylate

Guidance literature:: 5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate; With lithium trimethylstannyl; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

1,3-dibromo-propane; In tetrahydrofuran; at -78 - 20 ℃; for 12h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101427

Reference yield:

: 110-52-1
1,4-dibromo-butane

: 1374411-70-7
5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate

: 1374411-81-0
7-methyl 9a-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] (9aR)-2,3,4,9a-tetrahydro-1H-quinolizine-7,9a-dicarboxylate

: 1374411-82-1
7-methyl 9a-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] (9aS)-2,3,4,9a-tetrahydro-1H-quinolizine-7,9a-dicarboxylate

Guidance literature:: 5-methyl 2-[(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl] pyridine-2,5-dicarboxylate; With lithium trimethylstannyl; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

1,4-dibromo-butane; In tetrahydrofuran; N,N-dimethyl-formamide; at -78 - 60 ℃; for 12.33h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201101427