1-[(3-Methylphenyl)methyl]piperidin-4-amine

Base Information

Chemical Name:1-[(3-Methylphenyl)methyl]piperidin-4-amine
CAS No.:82378-82-3
Molecular Formula:C₁₃H₂₀N₂
Molecular Weight:204.315
Hs Code.:
ChEMBL ID:CHEMBL4547356
DSSTox Substance ID:DTXSID001260194

Synonyms:1-[(3-methylphenyl)methyl]piperidin-4-amine;82378-82-3;SCHEMBL6943838;CHEMBL4547356;DTXSID001260194;AKOS000128728;CS-0248919;1-[(3-Methylphenyl)methyl]-4-piperidinamine;EN300-41901;Z239097778

Suppliers and Price of 1-[(3-Methylphenyl)methyl]piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1-[(3-Methylphenyl)methyl]piperidin-4-amine

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:204.162648646
Heavy Atom Count:15
Complexity:185

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)CN2CCC(CC2)N

Technology Process of 1-[(3-Methylphenyl)methyl]piperidin-4-amine

There total 7 articles about 1-[(3-Methylphenyl)methyl]piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1-(m-methylbenzyl)-4-piperidone oxime

: 82378-82-3
1-(m-methylbenzyl)-4-aminopiperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 19h; Heating;

Reference yield:

: 203321-93-1
tert-butyl [1-(3-methylbenzyl)piperidin-4-yl]carbamate

: 82378-82-3
1-(m-methylbenzyl)-4-aminopiperidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

Reference yield:

: 620-19-9
1-chloromethyl-3-methyl-benzene

: 82378-82-3
1-(m-methylbenzyl)-4-aminopiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: Cs₂CO₃; KI / various solvent(s) / 5 h / 100 °C

2: PhI(CF₃CO₂)2 / acetonitrile; H₂O / 65 °C

With caesium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; potassium iodide; In water; acetonitrile; 2: Hoffmann rearrangement;
DOI:10.1081/NCN-100002493