N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

Base Information

• Chemical Name: N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine
• CAS No.: 1075253-41-6
• Molecular Formula: C₂₀H₁₄F₆N₆S
• Molecular Weight: 484.428

Synonyms:N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

Chemical Property of N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

There total 1 articles about N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine (1075253-40-5) → N2-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine (1075253-41-6)

Guidance literature:

With sodium dithionite; water; In acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jm800743q

Reference yield: 100.0%

trifluoromethylsulfonic anhydride (358-23-6) + N2-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine (1075253-41-6) → 3-[2,4-bis(trifluoromethyl)phenyl]-5-methyl-7-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine (1075253-34-7)

Guidance literature:

With trifluoroacetic acid; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/jm800743q

Reference yield: 99.0%

N2-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine (1075253-41-6) + acetic anhydride (108-24-7) → 3-[2,4-bis(trifluoromethyl)phenyl]-2,5-dimethyl-7-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-3H-imidazo[4,5-b]pyridine (1075253-33-6)

Guidance literature:

With acetic acid; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm800743q

upstream raw materials:

N-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-3-nitro-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-pyridinamine

Downstream raw materials:

3-[2,4-bis(trifluoromethyl)phenyl]-5-methyl-7-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

3-[2,4-bis(trifluoromethyl)phenyl]-5-methyl-7-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine

3-[2,4-bis(trifluoromethyl)phenyl]-2,5-dimethyl-7-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-3H-imidazo[4,5-b]pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1075253-41-6 N₂-[2,4-bis(trifluoromethyl)phenyl]-6-methyl-4-[3-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]-2,3-pyridinediamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send