(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

Base Information

Chemical Name:(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate
CAS No.:1421357-30-3
Molecular Formula:C₂₆H₂₄N₄O₃
Molecular Weight:440.502
Hs Code.:

Synonyms:(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

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Chemical Property of (E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

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Technology Process of (E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

There total 4 articles about (E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 100-43-6,329041-72-7
4-vinylpyridine

: 1421357-20-1
benzyl ((1-(benzyloxy)-3-iodo-1H-pyrazol-4-yl)methyl)carbamate

: 1421357-30-3
(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 90 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jm301473k

Reference yield:

: 229171-07-7
1-(benzyloxy)-4-iodo-1H-pyrazole

: 1421357-30-3
(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 18.5 h / 0 - 20 °C / Inert atmosphere

3: Iodine monochloride / water; acetic acid / 23 h / 85 °C

4: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / 2.5 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; isopropylmagnesium chloride; palladium diacetate; Iodine monochloride; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; water; acetic acid; acetonitrile;
DOI:10.1021/jm301473k

Reference yield:

: 1-benzyloxy-1H-pyrazole-4-carbonitrile

: 1421357-30-3
(E)-benzyl ((1-(benzyloxy)-3-(2-(pyridin-4-yl)vinyl)-1H-pyrazol-4-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 18.5 h / 0 - 20 °C / Inert atmosphere

2: Iodine monochloride / water; acetic acid / 23 h / 85 °C

3: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / acetonitrile / 2.5 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; palladium diacetate; Iodine monochloride; triethylamine; tris-(o-tolyl)phosphine; In methanol; water; acetic acid; acetonitrile;
DOI:10.1021/jm301473k