N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

Base Information

Chemical Name:N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide
CAS No.:1335093-81-6
Molecular Formula:C₂₀H₂₃F₂NO₄
Molecular Weight:379.404
Hs Code.:

Synonyms:N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

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Chemical Property of N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

Chemical Property:

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Technology Process of N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

There total 5 articles about N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335093-94-1
2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethanamine

: 331-25-9
(3-fluorophenyl)acetic acid

: 1335093-81-6
N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

Guidance literature:: (3-fluorophenyl)acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethanamine; In dichloromethane; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

: 914394-64-2
4-(2-fluoroethoxy)-3-methoxybenzaldehyde

: 1335093-81-6
N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate; acetic acid / 0.5 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With lithium aluminium tetrahydride; ammonium acetate; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.072

Reference yield:

: 1335093-90-7
(E)-1-(2-fluoroethoxy)-2-methoxy-4-(2-nitrovinyl)benzene

: 1335093-81-6
N-(2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethyl)-2-(3-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; methanol / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.072