4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1415928-54-9
Molecular Formula:C₁₉H₂₀ClN₃
Molecular Weight:325.841
Hs Code.:

Synonyms:4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

There total 2 articles about 4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171879-99-5
4-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine

: 1415928-54-9
4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / dichloromethane / 18 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water / 1 h / 65 °C

With N-iodo-succinimide; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1415928-52-7
4-chloro-3-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine

: 1415928-54-9
4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water / 1 h / 65 °C

With sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water;

Reference yield:

: 88398-97-4
1-methyl-1H-pyrazole-3-sulfonamide

: 1415928-54-9
4-chloro-1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

: 1415925-19-7
N-(1,6-dimethyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation;