(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

Base Information

Chemical Name:(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide
CAS No.:1380325-31-4
Molecular Formula:C₂₅H₂₇NO₂
Molecular Weight:373.495
Hs Code.:

Synonyms:(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

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Technology Process of (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

There total 6 articles about (R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1380325-24-5
(S,S)-N-(2-hydroxy-1,2-diphenylethyl)-N-methylpropionamide

: 100-39-0
benzyl bromide

: 1380325-31-4
(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: (S,S)-N-(2-hydroxy-1,2-diphenylethyl)-N-methylpropionamide; With pyridine; n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1.33333h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201200370

Reference yield:

: 301191-47-9
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide

: 1380325-31-4
(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.75 h / 0 - 23 °C / Inert atmosphere

3.1: pyridine; n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran; hexane / 1.33 h / -78 - 23 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/anie.201200370

Reference yield:

: 530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0
(1S,2S)-2-amino-1,2-diphenylethanol

: 1380325-31-4
(R)-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.75 h / 0 - 23 °C / Inert atmosphere

4.1: pyridine; n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran; hexane / 1.33 h / -78 - 23 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1002/anie.201200370