1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

Base Information

Chemical Name:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea
CAS No.:1402581-75-2
Molecular Formula:C₁₉H₁₈ClF₃N₆O₃S
Molecular Weight:502.905
Hs Code.:

Synonyms:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

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Chemical Property of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

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Technology Process of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

There total 13 articles about 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1402586-17-7
C₂₄H₂₆ClF₃N₆O₅S

: 1402581-75-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 23 ℃; for 2.5h;

Reference yield:

: 116853-75-9
C₈H₆ClF₃N₂

: 1402581-75-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

2: triethylamine / toluene / 20 h / 80 °C

3: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

4: dmap / acetonitrile / 50 °C

5: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 23 °C

With dmap; N-chloro-succinimide; ammonia; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1254713-76-2
hydrazonoyl chloride

: 1402581-75-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[(sulfamoylamino)methyl]phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / toluene / 20 h / 80 °C

2: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

3: dmap / acetonitrile / 50 °C

4: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 23 °C

With dmap; ammonia; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; toluene; acetonitrile;