tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate
CAS No.:1425972-75-3
Molecular Formula:C₂₂H₃₁NO₅S
Molecular Weight:421.558
Hs Code.:

Synonyms:tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1021169-68-5
4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran

: 1425970-61-1
tert-butyl 4-[(4,4,5,5 -tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]piperidine-1-carboxylate

: 1425972-75-3
tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.75h; Sealed tube; Microwave irradiation; Inert atmosphere;

Reference yield:

: 165119-50-6
4-[(4-bromophenyl)sulfanyl]tetrahydro-2H-pyran

: 1425972-75-3
tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.75 h / 100 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 305794-65-4
tert-butyl 4-(dibromomethylidene)piperidine-1-carboxylate

: 1425972-75-3
tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride / tetrahydrofuran; methanol / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; triphenylphosphine / 1,4-dioxane / Inert atmosphere; Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.75 h / 100 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; ammonium chloride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; water;