1021169-68-5

Basic information

• Product Name: 4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran
• Synonyms: 4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran
• CAS NO: 1021169-68-5
• Molecular Weight: 305.192
• Mol File: 1021169-68-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran(1021169-68-5)
• EPA Substance Registry System: 4-[(4-bromophenyl)sulfonyl]tetrahydro-2H-pyran(1021169-68-5)

Safety Data

• Hazardous Substances Data: 1021169-68-5(Hazardous Substances Data)

Upstream product

• 2081-44-9 Tetrahydro-pyran-4-ol 
• 25637-16-5 4-bromotetrahydro-2H-pyran 
• 25637-18-7 4-iodotetrahydropyran 
• 106-53-6 para-bromobenzenethiol 
• 165119-50-6 4-[(4-bromophenyl)sulfanyl]tetrahydro-2H-pyran 

Downstream Products

• 1021169-42-5 (R)-2-methyl-1-{2-[4'-(tetrahydro-pyran-4-sulfonyl)-biphenyl-4-yl]-ethyl}-pyrrolidine hydrochloride 
• 1350351-52-8 4,4,5,5-tetramethyl-2-(4-tetrahydropyran-4-ylsulfonylphenyl)-1,3,2-dioxaborolane 
• 1350351-34-6 3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol 
• 1350351-49-3 tert-butyl (3-(3-((3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)ethynyl)phenoxy)propyl)carbamate 
• 1021169-87-8 (R)-2-methyl-1-{2-[4'-(tetrahydro-pyran-4-sulfonyl)-biphenyl-4-yl]-ethyl}-pyrrolidine 
• 1450723-36-0 N-[(4-tetrahydropyran-4-ylsulfonylphenyl)methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450723-81-5 C₁₂H₁₇NO₃S 
• 1450724-16-9 C₁₉H₂₀N₂O₇S 
• 1450723-95-1 4-(tetrahydropyran-4-sulfonyl)benzonitrile 
• 1425972-75-3 tert-butyl 4-[4-(tetrahydro-2H-pyran-4-ylsulfonyl)benzylidene]piperidine-1-carboxylate 

Relevant articles and documents

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3- methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

The design of a new clinical candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by re

BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3- receptor. Compounds of the present invention and pharmaceutical compositions