(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Base Information

Chemical Name:(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide
CAS No.:209664-24-4
Molecular Formula:C₂₇H₃₇NO₃
Molecular Weight:423.596
Hs Code.:

Synonyms:(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

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Chemical Property of (R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Chemical Property:

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Technology Process of (R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

There total 6 articles about (R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209664-19-7
(R)-2-Isobutyl-4-oxo-5,5-diphenyl-pentanoic acid methyl ester

: 209664-24-4
(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

2: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 117-34-0
2,2-diphenylacetic acid

: 209664-24-4
(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) THF, 0 deg C, 0.5 h; room temperature, overnight, 2.) THF, hexane, -78 deg C, 0.5 h

2: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

3: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

4: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,1'-carbonyldiimidazole; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1

Reference yield:

: 189030-33-9
3-Oxo-4,4-diphenyl-butyric acid tert-butyl ester

: 209664-24-4
(R)-2-isobutyl-4-oxo-5,5-diphenylpentanoic acid ((S)-1-hydroxymethyl-3-methyl)butyl amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, room temperature, overnight, 2.) TFA, room temperature, 3.) benzene, reflux

2: LiOH*H₂O / methanol; H₂O / 70 - 75 °C

3: N-methylmorpholine, 1-HOBt, BOP / dimethylformamide / 0 - 23 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00009-1