4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester
• CAS No.: 186136-12-9
• Molecular Formula: C₃₁H₂₈O₄
• Molecular Weight: 464.561
• Mol file: 186136-12-9.mol

Synonyms:4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester

Chemical Property of 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester

There total 3 articles about 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloride (100-44-7) → 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester (186136-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF, room temperature, 1 h, 2.) reflux, 24 h

2: 1.) NaH / 1.) THF, 30 min, 2.) 48 h

With sodium hydride; potassium carbonate;

DOI:10.1021/jo961587w

Reference yield:

3,4-dihydroxybenzaldehyde (139-85-5) → 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester (186136-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF, room temperature, 1 h, 2.) reflux, 24 h

2: 1.) NaH / 1.) THF, 30 min, 2.) 48 h

With sodium hydride; potassium carbonate;

DOI:10.1021/jo961587w

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) + ethyl 4-(diethoxyphosphorylmethyl)benzoate (71441-08-2) → 4-[(E)-2-(3,4-Bis-benzyloxy-phenyl)-vinyl]-benzoic acid ethyl ester (186136-12-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 30 min, 2.) 48 h;

DOI:10.1021/jo961587w

upstream raw materials:

3,4-dibenzyloxybenzaldehyde

ethyl 4-(diethoxyphosphorylmethyl)benzoate

benzyl chloride

3,4-dihydroxybenzaldehyde