71441-08-2

Basic information

• Product Name: Benzoic acid, 4-[(diethoxyphosphinyl)methyl]-, ethyl ester
• Synonyms: diethyl (4-carbethoxybenzyl)phosphonate;diethyl p-(ethoxycarbonyl)benzylphosphonate;diethyl (4-carboethoxybenzyl)-phosphonate;diethyl 4-ethoxycarbonylbenzylphosphonate;Benzoic acid,4-[(diethoxyphosphinyl)methyl]-,ethyl ester;4-(diethoxy-phosphorylmethyl)benzoic acid ethyl ester
• CAS NO: 71441-08-2
• Molecular Formula: C14H21O5P
• Molecular Weight: 300.292
• Mol File: 71441-08-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(diethoxyphosphinyl)methyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(diethoxyphosphinyl)methyl]-, ethyl ester(71441-08-2)
• EPA Substance Registry System: Benzoic acid, 4-[(diethoxyphosphinyl)methyl]-, ethyl ester(71441-08-2)

Safety Data

• Hazardous Substances Data: 71441-08-2(Hazardous Substances Data)

Upstream product

• 99-94-5 p-Toluic acid 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 122-52-1 triethyl phosphite 
• 1137728-03-0 C₅H₁₂IO₃PZn 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 26496-94-6 Ethyl 4-(bromomethyl)benzoate 
• 6232-88-8 4-bromomethylbenzoic Acid 
• 762-04-9 Diethyl phosphonate 
• 64-17-5 ethanol 
• 28149-48-6 4-[(diethoxyphosphinyl)methyl]benzoic acid 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 

Downstream Products

• 97845-90-4 (Z)-Ethyl 4-(2,6-dimethyl-1,5-heptadienyl)benzoat 
• 97845-89-1 (E)-Ethyl 4-(2,6-dimethyl-1,5-heptadienyl)benzoate 
• 97845-96-0 (Z)-Ethyl 4-<4-(1-methoxycyclohexyl)-2-methyl-1-butenyl>benzoate 
• 97845-95-9 (E)-Ethyl 4-<4-(1-methoxycyclohexyl)-2-methyl-1-butenyl>benzoate 
• 88579-38-8 ethyl p-[(E)-2-(1,4,4-trimethyl-1,2,3,4-tetrahydro-6-quinolinyl)propenyl]benzoate 
• 669002-67-9 ethyl 4-(1,4-dioxa-spiro[4.5]dec-8-ylidenemethyl)-benzoate 
• 1208223-09-9 4-[2-(4'-tert-butyl-biphenyl-4-yl)-2-(4'-chloro-2'-methyl-biphenyl-4-yl)-vinyl]-benzoic acid ethyl ester 
• 1401063-71-5 C₁₂H₁₇O₃P 
• 1401063-68-0 C₁₃H₁₉O₄P 
• 1401063-67-9 ethyl 4-(aminomethyl)benzyl(methyl)phosphinate 
• 1401063-69-1 C₁₁H₁₇O₃P 
• 1401063-70-4 C₁₉H₂₀NO₄P 
• 936343-80-5 4-((E)-2-furan-2-yl-vinyl)-benzoic acid ethyl ester 
• 74519-03-2 trans-4'-carbethoxy-4-nitrostilbene 

Relevant articles and documents

A convenient method for the synthesis of aminomethylmonoalkylphosphinate

Starting from the readily available 4-methylbenzoic acid, an efficient protocol for the preparation of ethyl 4-(aminomethyl) benzyl (methyl) phosphinate (1), a novel aminomethylmonoalkylphosphinate was reported in this communication. The important step involves the selective monochlorination of phosphonic ester by POCl3 and forming the phosphonochloridate, and followed by nucleophilic addition of CH3MgBr to the acid chloride intermediate.

Direct conversion of benzylic and allylic alcohols to phosphonates

Benzyl phosphonate esters often serve as reagents in Horner-Wadsworth- Emmons reactions. In most cases, they can be prepared from benzylic alcohols via formation of the corresponding halide followed by an Arbuzov reaction. To identify a more direct synthesis of phosphonate esters, we have developed a one-flask procedure for conversion of benzylic and allylic alcohols to the corresponding phosphonates through treatment with triethyl phosphite and ZnI2.

Synthesis and evaluation of stilbenylbenzoxazole and stilbenylbenzothiazole derivatives for detecting β-amyloid fibrils

This paper describes a novel series of stilbenylbenzoxazole (SBO) and stilbenylbenzothiazole (SBT) derivatives for β-amyloid specific binding probes. These 24 compounds were synthesized and evaluated by competitive binding assay against β-amyloid 1-42 (Aβ42) aggregates using [125I]TZDM. All the derivatives displayed higher binding affinities with Ki value in the subnanomolar range (0.10-0.74 nM) than Pittsburgh Compound-B (PIB) (0.77 nM). Among these derivatives, SBT-2, 5-fluoroethoxy-2-{4-[2-(4-methylaminophenyl)vinyl]phenyl}benzothiazole, showed lowest Ki value (0.10 nM). In conclusion, the preliminary results suggest that these compounds are implying a possibility as a probe for detection of Aβ fibrils in Alzheimer's disease (AD) patients.