Technology Process of <2-hydroxy-2-phenylethoxy>methyldiphenylphosphine oxide
There total 9 articles about <2-hydroxy-2-phenylethoxy>methyldiphenylphosphine oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 35 percent / H2O / 3 h
2: 96 percent / imidazole / dimethylformamide / Ambient temperature
3: 92 percent / p-TsOH*H2O / CH2Cl2 / Ambient temperature
4: 84 percent / Bu4NF*3H2O / tetrahydrofuran / 0 °C
5: 1.) NaH / 1.) THF, 40 min, 50 deg C, 2.) THF, -10 deg C, 15 min and 80 deg C
6: 87 percent / 20percent H2SO4 / methanol / 1 h / Ambient temperature
With
1H-imidazole; sulfuric acid; tetrabutyl ammonium fluoride; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89330-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 31 percent / H2O / 4 h
2: 96 percent / imidazole / dimethylformamide / Ambient temperature
3: 92 percent / p-TsOH*H2O / CH2Cl2 / Ambient temperature
4: 84 percent / Bu4NF*3H2O / tetrahydrofuran / 0 °C
5: 1.) NaH / 1.) THF, 40 min, 50 deg C, 2.) THF, -10 deg C, 15 min and 80 deg C
6: 87 percent / 20percent H2SO4 / methanol / 1 h / Ambient temperature
With
1H-imidazole; sulfuric acid; tetrabutyl ammonium fluoride; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89330-3
