5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine
• CAS No.: 1346447-85-5
• Molecular Formula: C₂₁H₂₂ClN₅O₅S
• Molecular Weight: 491.955

Synonyms:5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine

Chemical Property of 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine

There total 8 articles about 5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)-N₂-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine (761440-16-8) + (2-methoxy-5-nitrophenyl)methanamine (40896-72-8) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine (1346447-85-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 100 ℃; for 12h;

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine (1346447-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

2-(isopropyl sulfanyl)nitrobenzene (70415-85-9) → 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-5-nitrobenzyl)pyrimidine-2,4-diamine (1346447-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 12 h / 100 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

ortho-nitrofluorobenzene

2-methoxy-5-nitrobenzyl bromide

2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methyl-pyrimidin-4-amine

(2-methoxy-5-nitrophenyl)methanamine

Downstream raw materials:

N₂-(5-amino-2-methoxybenzyl)-5-chloro-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

N-(3-(((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)methyl)-4-methoxyphenyl)acrylamide

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