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  • High quality 4-Pyrimidinamine, 2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]- supplier in China

    Cas No: 761440-16-8

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  • 1 Metric Ton

  • 30 Metric Ton/Month

  • Simagchem Corporation
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761440-16-8 Usage


2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine is a chemical compound that serves as a crucial reagent in the synthesis of anaplastic lymphoma kinase (ALK-5) inhibitors. These inhibitors are potent and selective, making them valuable in the development of anti-tumor treatments.


Used in Pharmaceutical Industry:
2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine is used as a reagent for the synthesis of ALK-5 inhibitors, which are employed as anti-tumor treatments. 2,5-dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine plays a significant role in the development of targeted therapies for cancer, specifically for malignancies where the ALK-5 enzyme is implicated.

Check Digit Verification of cas no

The CAS Registry Mumber 761440-16-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,1,4,4 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 761440-16:
148 % 10 = 8
So 761440-16-8 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names 2,5-dichloro-N-(2-propan-2-ylsulfonylphenyl)pyrimidin-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:761440-16-8 SDS

761440-16-8Downstream Products

761440-16-8Relevant articles and documents

Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties

Lei, Hongrui,Jiang, Nan,Miao, Xiuqi,Xing, Lingyun,Guo, Ming,Liu, Yang,Xu, Haowen,Gong, Ping,Zuo, Daiying,Zhai, Xin

, p. 297 - 309 (2019)

Aiming to identify novel potent ALK and ROS1 dual inhibitors, the relatively bulky piperidine fragment in ceritinib was replaced with substituted imidazolidin-2-one moiety which gave rise to a series of 2,4-diaryl-aminopyrimidine (DAAP) analogs (6–33). SAR studies were conducted based on cellular assays on five cell lines and most compounds exerted moderated to excellent activities. Among them, 15 showed excellent inhibitory activities against ROS1 and ALK positive cell lines, especially Ba/F3G1202R, with IC50 values ranging from 14 to 37 nM. As a continuation, several compounds were tested in enzymatic assays and 15 displayed encouraging activities against wild-type ALK (1.2 nM), ROS1(0.43 nM) as well as extremely resistant ALKL1196M and ALKG1202R mutants with IC50 values of 0.73 nM and 6.7 nM, respectively. To our delight, both cellular and enzymatic results of 15 were in good accordance with western blot assays on H2228 and HCC78 cell lines. Importantly, pharmacokinetic (PK) profiles of 15 were obtained with quite satisfying AUC and Cmax values. Besides, the binding models of 15 with ALKWT, ALKG1202R and ROS1 clearly present the essential interactions within the active site.

CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor


, (2021/03/31)

The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.



Paragraph 00212-00213, (2021/09/04)

Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.

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