3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

Base Information

Chemical Name:3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole
CAS No.:1338597-26-4
Molecular Formula:C₂₃H₁₈FN₃O₂S
Molecular Weight:419.479
Hs Code.:

Synonyms:3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

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Chemical Property of 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

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Technology Process of 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

There total 6 articles about 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 446-48-0
o-fluorobenzyl bromide

: 1338597-15-1
5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

: 1338597-26-4
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

Guidance literature:: With sodium hydroxide; In acetonitrile; Reflux;
DOI:10.1016/j.bmc.2011.08.063

Reference yield:

: 4442-54-0
2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

: 1338597-26-4
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: hydrazine hydrate / ethanol / 120 h / Reflux

3.1: ethanol / 0.5 h / Reflux

4.1: sodium hydroxide / 0.5 h / Reflux

4.2: 20 °C / pH 3 - 4

5.1: sodium hydroxide / acetonitrile / Reflux

With sulfuric acid; hydrazine hydrate; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2011.08.063

Reference yield:

: 1009922-41-1
2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide

: 1338597-26-4
3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-4-phenyl-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 0.5 h / Reflux

1.2: 20 °C / pH 3 - 4

2.1: sodium hydroxide / acetonitrile / Reflux

With sodium hydroxide; In acetonitrile;
DOI:10.1016/j.bmc.2011.08.063