{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine

Base Information

• Chemical Name: {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine
• CAS No.: 1301239-46-2
• Molecular Formula: C₁₉H₂₁NO₂
• Molecular Weight: 295.381
• Mol file: 1301239-46-2.mol

Synonyms:{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine

Chemical Property of {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine

There total 3 articles about {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

Benzhydrylamine (91-00-9) + (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde (22323-80-4) → {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine (1301239-46-2)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-0030-1258407

Reference yield:

calcium bis[(2R)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)acetate] (98733-24-5) → {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine (1301239-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium hypochlorite; sodium acetate; acetic acid / water / 0.58 h / 50 °C

2: magnesium sulfate / dichloromethane / 0.5 h / 20 °C

With calcium hypochlorite; sodium acetate; magnesium sulfate; acetic acid; In dichloromethane; water;

DOI:10.1055/s-0030-1258407

Reference yield:

5,6-O-isopropylidene-L-ascorbic acid (15042-01-0) → {[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methylene}-1,1-diphenylmethanamine (1301239-46-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dihydrogen peroxide; calcium carbonate / water / 4 h / 20 - 50 °C

2: calcium hypochlorite; sodium acetate; acetic acid / water / 0.58 h / 50 °C

3: magnesium sulfate / dichloromethane / 0.5 h / 20 °C

With calcium hypochlorite; dihydrogen peroxide; sodium acetate; magnesium sulfate; acetic acid; calcium carbonate; In dichloromethane; water;

DOI:10.1055/s-0030-1258407

upstream raw materials:

calcium bis[(2R)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl](hydroxy)acetate]

Benzhydrylamine

(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

5,6-O-isopropylidene-L-ascorbic acid

Downstream raw materials:

(3S,4S)-3-acetyl-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)azetidin-2-one

(3S,4S)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-3-[(1S)-1-hydroxyethyl]azetidin-2-one

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl benzoate

(1S)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl methanesulfonate