(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

Base Information

Chemical Name:(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one
CAS No.:1289512-72-6
Molecular Formula:C₂₆H₃₆O₃Si
Molecular Weight:424.656
Hs Code.:

Synonyms:(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

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Chemical Property of (7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

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Technology Process of (7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

There total 1 articles about (7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1826-67-1
vinyl magnesium bromide

: 786668-27-7
(S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-pyran-2-one

: 1289512-72-6
(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

Guidance literature:: vinyl magnesium bromide; (S)-6-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-pyran-2-one; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201001411

Reference yield: 52.0%

: 1289512-72-6
(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

: 1289512-65-7
(1S,2R)-1-((2R,4R,5R)-5-{(1S,3R,5S)-1-[(benzyloxy)methyl]-5-methyl-2,8-dioxabicyclo[3.2.1]octan-3-yl}-4-[(tert-butyldimethylsilyl)oxy]-2-methyltetrahydrofuran-2-yl)-1-[(tert-butyldimethylsilyl)oxy]but-3-en-2-ol

: 1289512-90-8
(5S,6R,13S,14S,E)-5-((2R,4R,5R)-5-{(1S,3R,5S)-1-[(benzyloxy)methyl]-5-methyl-2,8-dioxabicyclo[3.2.1]octan-3-yl}-4-[(tert-butyldimethylsilyl)oxy]-2-methyltetrahydrofuran-2-yl)-6,13-dihydroxy-2,2,3,3,14,18,18-heptamethyl-17,17-diphenyl-4,16-dioxa-3,17-disilanonadec-7-en-9-one

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 17h; Inert atmosphere; Reflux;
DOI:10.1002/ejoc.201001411

Reference yield: 52.0%

: 1289512-72-6
(7S,8S)-9-[(tert-butyldiphenylsilyl)oxy]-7-hydroxy-8-methylnon-1-en-3-one

: 1289512-65-7
(1S,2R)-1-((2R,4R,5R)-5-{(1S,3R,5S)-1-[(benzyloxy)methyl]-5-methyl-2,8-dioxabicyclo[3.2.1]octan-3-yl}-4-[(tert-butyldimethylsilyl)oxy]-2-methyltetrahydrofuran-2-yl)-1-[(tert-butyldimethylsilyl)oxy]but-3-en-2-ol

: 1289512-92-0
C₆₀H₉₂O₉Si₃

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In dichloromethane; for 20h; Inert atmosphere; Reflux;
DOI:10.1002/ejoc.201001411