10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene

Base Information

• Chemical Name: 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene
• CAS No.: 1263143-06-1
• Molecular Formula: C₂₀H₁₃OPS
• Molecular Weight: 332.362
• Mol file: 1263143-06-1.mol

Synonyms:10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene

Chemical Property of 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene

There total 13 articles about 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-bromo-2-(2-bromophenyl)benzo[b]thiophene (1263143-03-8) + Dichlorophenylphosphine (644-97-3) → 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene (1263143-06-1)

Guidance literature:

3-bromo-2-(2-bromophenyl)benzo[b]thiophene; With n-butyllithium; In diethyl ether; hexane; at -20 ℃; for 0.333333h;

Dichlorophenylphosphine; In diethyl ether; hexane; at -20 - 20 ℃; for 15h;

Reference yield: 85.0%

2-phenylbenzo[b]thiophene (1207-95-0) + phenylphosphinic acid (1779-48-2) → 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene (1263143-06-1)

Guidance literature:

With dmap; trifluoromethylsulfonic anhydride; In cis-1,2-Dichloroethylene; at 90 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00944

Reference yield: 84.0%

(2-(benzo[b]thiophen-2-yl)phenyl)phenylphosphine oxide → 10-phenyl-10-oxo-[1]benzophospholo[3,2-b][1]benzothiophene (1263143-06-1)

Guidance literature:

With trifluoromethylsulfonic anhydride; In toluene; at 90 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00219

upstream raw materials:

3-bromo-2-(2-bromophenyl)benzo[b]thiophene

10-phenyl-10H-benzo[b]phosphindolo[2,3-d]thiophene

2,3-dibromobenzo[b]thiophene

Dichlorophenylphosphine

Downstream raw materials:

C₂₀H₁₃O₂PS

CF₃O₃S^(1-)*C₂₁H₁₆O₂PS⁽¹⁺⁾

C₁₄H₈SO₂P(O)Ph

(C₁₄H₈SO₂PPh)BH₃

Refernces

• 1、 Chen, Siyu,Ding, Haixin,Hua, Yuhui,Huang, Haiyang,Li, Chenchen,Liu, Fen,Song, Xian-Rong,Xiao, Qiang,Yuan, Chengxiong. "Synthesis of (Thio)Furan-Fused Phospholes via Phosphonation Cyclization and a Base-Promoted Phospha-Friedel-Crafts Reaction". . . Retrieved 2022/02/07.
• 2、 Nishimura, Kazutoshi,Hirano, Koji,Miura, Masahiro. "Synthesis of Dibenzophospholes by Tf2O-Mediated Intramolecular Phospha-Friedel-Crafts-Type Reaction". supporting information. p. 1467 - 1470. Retrieved 2019/02/26.