(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

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Chemical Name:(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate
CAS No.:1401462-52-9
Molecular Formula:C₂₅H₂₅N₅O₃S
Molecular Weight:475.571
Hs Code.:

Synonyms:(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

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Chemical Property of (S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

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Technology Process of (S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

There total 5 articles about (S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1401462-51-8
(S)-5-chloro-N-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenyl)thiazolo[5,4-d]pyrimidin-7-amine

: 171364-80-0
methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1401462-52-9
(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

Guidance literature:: With sodium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(S)-2-methylpyrrolidine

: 1401462-52-9
(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / zinc / 1,4-dioxane; water / 2 h / 20 °C

2.2: pH 8

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 30 °C

4.1: sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1401462-52-9
(S)-methyl 4-(7-(3-methoxy-5-(2-methylpyrrolidin-1-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / zinc / 1,4-dioxane; water / 2 h / 20 °C

2.2: pH 8

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 30 °C

4.1: sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In 1,4-dioxane; water; dimethyl sulfoxide;