4'-chloro-2-hydroxybenzophenone

Base Information

• Chemical Name: 4'-chloro-2-hydroxybenzophenone
• CAS No.: 2985-79-7
• Molecular Formula: C₁₃H₉ClO₂
• Molecular Weight: 232.666
• Mol file: 2985-79-7.mol

Synonyms:4'-chloro-2-hydroxybenzophenone

Chemical Property of 4'-chloro-2-hydroxybenzophenone

Chemical Property:

• Melting Point: 77–78°C

Purity/Quality:

98% ^*data from raw suppliers

4’-Chloro-2-hydroxy-benzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4’-Chloro-2-hydroxy-benzophenone is a useful compound to investigate the effects of substituents on photo-antioxidant abilities of 2-hydroxybenzoyl compounds that can?prevent?autooxidation of plastics under UV light.4’-Chloro-2-hydroxy-benzophenone can also utilized to develop novel?Azomethine Prodrugs of (R)-α-Methylhistamine.

Technology Process of 4'-chloro-2-hydroxybenzophenone

There total 36 articles about 4'-chloro-2-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate + salicylaldehyde (90-02-8) → 4'-chloro-2-hydroxybenzophenone (2985-79-7)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; cesium acetate; In acetonitrile; at 20 ℃; for 20h; Sealed tube;

DOI:10.1039/c6ob00825a

Reference yield: 92.0%

1-Chloro-4-iodobenzene (637-87-6) + salicylaldehyde (90-02-8) → 4'-chloro-2-hydroxybenzophenone (2985-79-7)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

Reference yield: 81.0%

2-[(4-chlorophenyl)(pyrolidin-1-yl)methyl]phenol → 4'-chloro-2-hydroxybenzophenone (2985-79-7)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); silver(l) oxide; In water; at 100 ℃; for 6h;

DOI:10.1016/j.tetlet.2020.152487

upstream raw materials:

phenyl 4-chlorobenzoate

5-tert-butyl-4'-chloro-2-methoxy-benzophenone

chlorobenzene

salicyloyl chloride

Downstream raw materials:

2-((4-chlorophenyl)(imino)methyl)phenol

(S)-2-(amino(4-chlorophenyl)methyl)phenol

(R)-(4-chlorophenyl)(phenyl)methylamine

(α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride

Refernces

• 1、 Prasanna Kumari, Subramaniyan,Suresh, Pavithira,Muthukumar, Vijayashree,Selva Ganesan, Subramaniapillai. "Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives". . . Retrieved 2020/10/13.
• 2、 Clarkson, Guy J.,Wills, Martin,Zheng, Ye. "Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols". supporting information. . Retrieved 2020/05/05.